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Abbreviations ASUD alcohol and other substance use disorder AUD alcohol use disorder BMI body mass index CNS central nervous system DPP-4 dipeptidyl peptidase-4 DSM-5 Diagnostic and Statistical Manual of Mental Disorders version 5 EX-4 exendin-4 FDA Food and Drug Administration GABA γ-aminobutyric acid GLP-1 glucagon-like peptide-1 GLP-1R glucagon-like peptide-1 receptor GLP-1RA glucagon-like peptide-1 receptor agonist NAc nucleus accumbens NRT nicotine replacement therapy NTS nucleus tractus solitarius OUD opioid use disorder PFC prefrontal cortex RCT randomized controlled trial T2DM type 2 diabetes mellitus TUD tobacco use disorder VTA ventral tegmental area Contributor Information Nirupam M Srinivasan, School of Medicine, University of Galway, Galway H91 TK33, Ireland

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